What is Nutrient drug interaction?

 

Nutrients commonly effected by drugs;

 Some nutrients are are more widely recognized as being affected by drugs then others. Traditionally the nutrients most often sighted in drug induced malnutrition were summarized by Roe and seconded by Williams as follow .

• Vitamin B12 because its digestion, absorption and utilization can be impacted at several points and by multiple drugs and conditions.

• B vitamins in general secondary to initial low body stores leading to earlier depletion.

• Iron and other nutrients important in red blood cell production.

• Calcium and vitamin D important to maintenance of healthy bonds in adults and avoidance of rickets in children.

More attention has recently been placed on drug induced deficiencies of folate, thiamin, protein. increased number of these reactions have occurred as a result of drugs having greater potential and specificity. Special attention has been paid to the numerous drugs that negatively influence folate status.

Folate and pyridoxine antagonist:

Drugs that work by interfering with metabolic path ways dependent on folate and B6 coenzymes:

The wide spread use of certain drugs in cardiovascular disease has led to a much greater appreciation of the potential dangerous of poor thiamine status because that syndrome may be perceived as simply another symptom of the underline cardiac disease itself.
Another example is the real influence of drugs on the many disease states that may be mis diagnosed as dementia or Alzheimer's disease.

 Such masqueraders may include vitamin deficiency, drug drug interactions or water and sodium imbalances.

When checking vitamin B12 status by biochemical methods the most commonly used test is the shillings test. All the this is a valid and valuable test for identifying mal absorption secondary to lack of intrinsic factor it does little to identify other causes of poor B12 status.

Lack of dietary folate or drugs interfering with folate both can lower vitamin B12 status. Among patients with marginal folic status the requirement for B12 increase as different pathways are used.
In the total picture the most common symptoms associated with drugs influence on nutritional status may we'll be commonly occuring symptoms, such as:

• Dry mouth 

• Nausea 

• Vomiting 

• Constipation 

• Diarrhea 

That discourage adequate amount of food.

Monitoring the influence of drugs on nutritional status must begin with a general recognition of the importance of nutrition in total health and in disease management.  
starting points of nutritional monitoring in drugs regimens:

• History of clinical diseases

•  drugs intake

•  physical examination

How do drug effect nutrient?

What is nutrient and drug interaction?

What drug interact with vitamin?